What question did this study set out to answer?

To identify clinical, historical, demographic, and familial predictors associated with treatment response to somatic interventions in patients presenting with acute mania.

July 1, 1975Archives of General Psychiatry

Acute Mania

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Authors

MTMichael Alan TaylorUniversity of Alabama at Birmingham

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Implication

Observational study reveals distinct clinical predictors of somatic treatment response in acute mania, suggesting euphoric symptoms and personality traits determine therapeutic success.

Key Points

To identify clinical, historical, demographic, and familial predictors associated with treatment response to somatic interventions in patients presenting with acute mania.
Evaluated 58 patients satisfying research diagnostic criteria for mania.
Assessed demographic variables, clinical history, presentation, and family psychiatric history against therapeutic responses to somatic modalities, including lithium carbonate, neuroleptics, and electric convulsive therapy.
Nearly two thirds of patients exhibited an excellent response to somatic treatment, especially lithium ion, whereas one third responded poorly to lithium, neuroleptics, or electroconvulsive therapy.
Treatment responders frequently presented with euphoric mood, grandiose delusions, and cyclothymic premorbid personalities, while nonresponders presented with formal thought disorder, incomplete auditory hallucinations, and depressive-withdrawn personalities.
Responders showed a nonsignificant trend toward higher genetic loading for affective illness and alcoholism, but groups did not differ by onset age, illness duration, or episode frequency.

Cite This Study

Michael Alan Taylor (1975) studied this question.

synapsesocial.com/papers/6a70804fe36a167817e249ee https://doi.org/10.1001/archpsyc.1975.01760250055005

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Implication

Observational study reveals distinct clinical predictors of somatic treatment response in acute mania, suggesting euphoric symptoms and personality traits determine therapeutic success.

Acute Mania

Discussion

Member takes

Implication

Key Points

Cite This Study

Acute Mania

Discussion

Member takes

Implication

Key Points

Cite This Study

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