Why the study?
What is the optimal second blood pressure-lowering drug for patients with hypertension not controlled on monotherapy?
Population
Patients with hypertension requiring a second blood pressure-lowering drug to reach blood pressure control
Design
Review
Authors
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Empirical choice of second antihypertensive persists; leaves open need for RCTs on hard outcomes.
What is the optimal second blood pressure-lowering drug for patients with hypertension not controlled on monotherapy?
The choice of a second antihypertensive agent remains largely empirical due to a lack of randomized trials comparing hard clinical outcomes.
Fuchs et al. (2007) studied this question.
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