Why the study?
The diagnosis and treatment of new-onset systolic dysfunction can be challenging, particularly in patients presenting with cardiogenic shock.
Does discontinuation of clozapine improve systolic function in patients with clozapine-induced cardiomyopathy?
Does discontinuation of clozapine improve systolic function in patients with clozapine-induced cardiomyopathy?
Clozapine can induce severe, potentially reversible cardiomyopathy presenting as cardiogenic shock, highlighting the need for prompt recognition and drug discontinuation.
Clozapine may induce reversible cardiomyopathy presenting as shock; case extends sparse reports but leaves open need for prospective surveillance studies.
The diagnosis and treatment of new-onset systolic dysfunction can be challenging, particularly in patients presenting with cardiogenic shock. We present a case of a young African-American man who was admitted for cardiogenic shock following an admission a month earlier for treatment- resistant psychosis. He was diagnosed with medication-induced cardiomyopathy, which resolved with a remarkable recovery of his systolic function after discontinuation of the culprit medication, clozapine.
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Hariri et al. (2023) studied this question.
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