Why the study?
Does a single period of exercise prevent ischemia/reperfusion-induced ventricular fibrillation and improve survival in dogs undergoing coronary occlusion?
Population
Dogs subjected to a 25 min occlusion of the left anterior descending coronary artery.
Comparison
A single period of treadmill exercise 24 or 48… vs Control dogs subjected to the same coronary…
Design
Preclinical
Follow-up
24 or 48 hours after exercise
Authors
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Single-session exercise may confer delayed antiarrhythmic protection in canine ischemia; hypothesis-generating for nitric oxide pathways before human trials.
Does a single period of exercise prevent ischemia/reperfusion-induced ventricular fibrillation and improve survival in dogs undergoing coronary occlusion?
A single session of exercise provides delayed cardioprotection against ischemia/reperfusion-induced arrhythmias and mortality in a canine model, an effect that appears to be mediated by nitric oxide.
Babai et al. (2002) studied this question.
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