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June 1, 2001AJP Heart and Circulatory Physiology

Persistence of gap junction communication during myocardial ischemia

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Population

End-to-end connected adult rat cardiomyocytes and isolated rat hearts submitted to simulated or nonflow…

Comparison

Gap junction blocker 18alpha-glycyrrhetinic acid vs Nonconnected cell pairs or connected cells…

Design

Preclinical

Follow-up

Up to 2 hours of ischemia

Authors

MRMarisol Ruiz‐MeanaDGDavid García‐DoradoSLSinead Lane

Discussion

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Overview

Hypothesis-generating for gap junction-mediated injury spread in ischemia; should not yet influence clinical decisions.

Structured PICO

P
Population
End-to-end connected adult rat cardiomyocytes and isolated rat hearts submitted to simulated or nonflow ischemia
I
Intervention
Gap junction blocker 18alpha-glycyrrhetinic acid
C
Comparator
Nonconnected cell pairs or connected cells without blocker
O
Outcome
Interval between rigor onset, rate of intracellular Ca2+ rise, and gap junction permeability (Lucifer yellow transfer)surrogate

Gap junction-mediated communication allows propagation of rigor in ischemic myocytes and persists after rigor development despite acidosis and increased intracellular calcium.

Cite This Study

Ruiz‐Meana et al. (2001) studied this question.

synapsesocial.com/papers/6a7082e1e5469ee92be13bbahttps://doi.org/10.1152/ajpheart.2001.280.6.h2563
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Direct observation of the "oxygen paradox" in single rat ventricular myocytes.1985 · 97 citations
  2. 2Paradoxical Improvement of Impulse Conduction in Cardiac Tissue by Partial Cellular Uncoupling1997 · 292 citations
  3. 3Propagation of Cardiomyocyte Hypercontracture by Passage of Na + Through Gap Junctions1999 · 113 citations
  4. 4Simulated Ischemia Increases the Susceptibility of Rat Cardiomyocytes to Hypercontracture1997 · 49 citations
  5. 5Electrical uncoupling and increase of extracellular resistance after induction of ischemia in isolated, arterially perfused rabbit papillary muscle.1987 · 358 citations