Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1998AJP Cell Physiology

Modulation of Ca2+-gated cardiac muscle Ca2+-release channel (ryanodine receptor) by mono- and divalent ions

View Full Paper
Ask AI
Bookmark
Share

Population

Cardiac muscle Ca(2+)-release channel (ryanodine receptor)

Design

Preclinical

Authors

WLWei LiuNorthwest Women's and Children's HospitalDPDaniel A. PasekUniversity of North Carolina at Chapel HillGMGerhard MeissnerElectrophysiology

Discussion

Loading...

Member takes

Implication

Animal data map ryanodine receptor ion regulation; leaves open translation to human arrhythmia or heart failure therapies.

Structured PICO

P
Population
Cardiac muscle Ca(2+)-release channel (ryanodine receptor)
I
Intervention
Mono- and divalent ions (choline chloride, KCl, CsCl, NaCl, LiCl, Sr2+, Mg2+, Ba2+)
O
Outcome
[3H]ryanodine-binding measurements (Ca2+ binding affinities of activation and inactivation sites)surrogate

This basic science study elucidates the regulatory mechanisms of mono- and divalent ions on the cardiac ryanodine receptor, highlighting competitive binding at activation and inactivation sites.

Cite This Study

Liu et al. (1998) studied this question.

synapsesocial.com/papers/6a70836dac440176ef292ddfhttps://doi.org/10.1152/ajpcell.1998.274.1.c120
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rapid calcium release from cardiac sarcoplasmic reticulum vesicles is dependent on Ca2+ and is modulated by Mg2+, adenine nucleotide, and calmodulin.1987 · 495 citations
  2. 2Selective Binding of FKBP12.6 by the Cardiac Ryanodine Receptor1996 · 254 citations
  3. 3Mechanism of early ischemic contractile failure. Inexcitability, metabolite accumulation, or vascular collapse?1991 · 61 citations
  4. 4Ryanodine Receptor/Ca2+ Release Channels and Their Regulation by Endogenous Effectors1994 · 929 citations
  5. 5Cytosolic Free Magnesium Levels in Ischemic Rat Heart1989 · 233 citations