Why the study?
Does dextran 70 alone or in combination with pneumatic calf compression prevent 125I-fibrinogen-detectable deep vein thrombosis compared to pneumatic compression alone in general surgical patients?
Does dextran 70 alone or in combination with pneumatic calf compression prevent 125I-fibrinogen-detectable deep vein thrombosis compared to pneumatic compression alone in general surgical patients?
Dextran 70 is more effective than pneumatic compression alone for preventing postoperative deep vein thrombosis, but it significantly increases the risk of postoperative bleeding.
Answers are grounded in this paper and cite their sources.
Favors dextran regimens over pneumatic compression alone for postoperative DVT prevention despite bleeding risk; extends comparative prophylaxis evidence in general surgery.
Seven general surgical units co-operated in a clinical trial of dextran 70 and pneumatic calf compression alone and in combination in the preventing of 125I-fibrinogen-detectable deep vein thrombosis in 305 patients. Both dextran regimens were significantly more effective than pneumatic compression alone. Pulmonary embolism was diagnosed in 14 patients, but there was no significant difference in incidence among the three treatment groups. In patients receiving dextran there was no greater median operative blood loss but there was a significantly greater incidence of postoperative bleeding complications.
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Smith et al. (1978) studied this question.
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