Why the study?
Do low doses of subcutaneous calcium heparinate or intramuscular sodium pentosan polysulfate prevent postoperative deep vein thrombosis in surgical patients?
Do low doses of subcutaneous calcium heparinate or intramuscular sodium pentosan polysulfate prevent postoperative deep vein thrombosis in surgical patients?
Prophylactic administration of low-dose calcium heparinate or sodium pentosan polysulfate substantially reduces the incidence of postoperative deep vein thrombosis compared to no treatment.
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Supports low-dose calcium heparinate for postoperative DVT prophylaxis in surgical patients; confirms substantial risk reduction in this RCT.
Deep vein thrombosis and its sequel, pulmonary embolus, are possibly the greatest threats to recovery after surgical operation. In a randomized, controlled clinical trial in which the 125I-fibrinogen uptake test, Doppler ultrasound, and phlebography were used for diagnosis, it was found that low doses of calcium heparinate administered subcutaneously and sodium pentosan polysulfate intramuscularly were effective in preventing deep vein thrombosis (DVT), postoperatively. The incidence of DVT was as follows: 9% in the group treated with heparinate; 15% in the group treated with sodium pentosan polysulfate; nad 51% in the untreated control group.
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Stephen N. Joffe (1976) studied this question.
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