February 3, 2004Circulation ResearchOpen Access

Sarcoplasmic Reticulum Calcium Content Fluctuation Is the Key to Cardiac Alternans

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Population

Rat ventricular myocytes

Comparison

Small depolarizing pulses and brief exposure to… vs Control conditions

Design

Preclinical

Authors

MDM.E. DíazUniversity of Edinburgh SOStephen O’NeillQueen's University Belfast DEDavid EisnerElectrophysiology

Discussion

Member takes

Implication

SR Ca²⁺ alternation drives Ca²⁺ alternans in animal models; leaves open translation to human arrhythmia mechanisms.

Structured PICO

Population

Rat ventricular myocytes

Intervention

Small (20 mV) depolarizing pulses and brief exposure to Na(+)-free solution

Comparator

Control conditions

Outcome

Sarcoplasmic reticulum (SR) Ca(2+) content and systolic Ca(2+) transient amplitudesurrogate

Cardiac alternans is driven by beat-to-beat fluctuations in sarcoplasmic reticulum calcium content and its steep relationship with calcium release and efflux.

Cite This Study

Díaz et al. (2004) studied this question.

synapsesocial.com/papers/6a7085992163a0a01bc4bcd6 https://doi.org/10.1161/01.res.0000119923.64774.72

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Sarcoplasmic Reticulum Calcium Content Fluctuation Is the Key to Cardiac Alternans

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Sarcoplasmic Reticulum Calcium Content Fluctuation Is the Key to Cardiac Alternans

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider