Antihypertensive drug treatment changes in the general population: the colaus study
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Population
772 hypertensive subjects initially aged 35-75 years living in Lausanne, Switzerland, from the…
Design
Cohort
Follow-up
median 5.4 years
Authors
Discussion
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Implication
Antihypertensive modifications linked to uncontrolled HTN and obesity in Swiss cohort; leaves open optimal strategies pending prospective trials.
Structured PICO
P
Population
772 hypertensive subjects (371 women) initially aged 35-75 years living in Lausanne, Switzerland, from the population-based CoLaus study.
O
Outcome
Changes in antihypertensive drug treatment (continuers, switchers, combiners, discontinuers) and associated factors.
In a Swiss population-based cohort, ARBs replaced diuretics as the most commonly prescribed antihypertensive drug over 5 years, and treatment modifications were associated with uncontrolled baseline hypertension and overweight/obesity.
Limitations
- Modest participation rate (41%)
- Possible health-conscious bias
- No record of adverse effects
- Lack of objective adherence assessment
- Misclassification due to outdated prescription boxes and no dosage information
Cite This Study
Christe et al. (2014) studied this question.
Topics
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