Why the study?
The study aimed to assess the associations of body fat levels and distribution with metabolic profiles and 24-hour blood pressure in young adults with primary hypertension.
Is visceral fat associated with metabolic profiles and nocturnal blood pressure fall in young adults with primary hypertension?
Is visceral fat associated with metabolic profiles and nocturnal blood pressure fall in young adults with primary hypertension?
In young adults with primary hypertension, a higher visceral fat to weight ratio is associated with a blunted nocturnal systolic blood pressure fall, particularly in males.
Should not yet alter management in young hypertensives; leaves open whether visceral fat drives metabolic and BP abnormalities.
The aims of this study were to assess associations of body fat levels and distribution with metabolic profiles and 24-hour blood pressure in young adults with primary hypertension. Visceral fat (VF) was estimated using dual-energy X-ray absorptiometry. VF was highly significantly associated with a high frequency of overweight/obesity, impaired fasting glucose, increased levels of triglycerides and LDL-cholesterol, and lowered level of HDL-cholesterol. The value of systolic blood pressure (SBP) nocturnal fall was similar between patients receiving RAAS inhibitors, beta-blockers, and calcium channel blockers. In multiple regression, the VF/weight ratio after adjusting for age, gender, total fat, and chronotherapeutic drug delivery was associated with the percentage SBP nocturnal fall (β = -.3108; 95% CI: -0.5923; -0.0980; P = .013). In males, excess VF increased the odds by 2.3 times for non-dipping blood pressure. Our results suggest that in young adult hypertensives, the VF/weight ratio might be associated with non-dipping blood pressure.
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Miazgowski et al. (2019) studied this question.
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