What question did this study set out to answer?

To assess whether a blunted nocturnal fall in blood pressure is associated with more advanced cardiac and vascular damage in recently diagnosed, untreated essential hypertension.

September 1, 1999Journal of Hypertension

Impact of nocturnal fall in blood pressure on early cardiovascular changes in essential hypertension

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Why the study?

Does a blunted nocturnal fall in blood pressure associate with more advanced cardiac and vascular damage in recently diagnosed, never-treated patients with mild essential hypertension?

Population

111 recently diagnosed and never-treated patients with mild essential hypertension (77 men, 34 women)

Comparison

Blunted nocturnal fall in blood pressure vs Normal nocturnal fall in blood pressure

Design

Cross-sectional

Authors

CCCesare CuspidiPreventive Cardiology LLLaura LonatiJagiellonian University LSLorena SampieriUniversity of Milan

Discussion

Member takes

Implication

No link between non-dipping and early organ damage in mild hypertension; leaves open prognostic value for progression in untreated patients.

Key Points

To assess whether a blunted nocturnal fall in blood pressure is associated with more advanced cardiac and vascular damage in recently diagnosed, untreated essential hypertension.
Evaluated 111 recently diagnosed and never-treated patients with mild essential hypertension using 24-hour ambulatory blood pressure monitoring, echocardiography, and carotid ultrasonography.
Categorized patients as dippers (>10% nocturnal systolic and diastolic blood pressure fall; n=78) or non-dippers (≤10% fall; n=33).
Dippers and non-dippers presented left ventricular mass index values of 104 versus 105 g/m2, carotid internal diameter of 5.8 versus 5.9 mm, and intima-media thickness of 0.66 versus 0.64 mm.
Carotid plaque prevalence was 25% in dippers compared to 29% in non-dippers.
Correlations of daytime and night-time blood pressure with left ventricular mass and carotid wall thickness showed no differences, including when stratified across 77 men and 34 women.

Structured PICO

Does a blunted nocturnal fall in blood pressure associate with more advanced cardiac and vascular damage in recently diagnosed, never-treated patients with mild essential hypertension?

Population

111 recently diagnosed and never-treated patients with mild essential hypertension (77 men, 34 women)

Intervention

Blunted nocturnal fall in blood pressure (non-dippers, ≤10% fall in SBP and DBP, n=33)

Comparator

Normal nocturnal fall in blood pressure (dippers, >10% fall in SBP and DBP, n=78)

Outcome

Cardiac and vascular damage assessed by left ventricular mass index, common carotid internal diameter, intima-media thickness, and carotid plaques prevalencesurrogate

A blunted nocturnal fall in blood pressure does not appear to be associated with more advanced early cardiac and vascular changes in patients with recently diagnosed, mild essential hypertension.

Cite This Study

Cuspidi et al. (1999) studied this question.

synapsesocial.com/papers/6a76cd234fe2e6ffd8ec2e6e https://doi.org/10.1097/00004872-199917090-00015

Topics

Hypertension management Echocardiography

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Implication

No link between non-dipping and early organ damage in mild hypertension; leaves open prognostic value for progression in untreated patients.

Impact of nocturnal fall in blood pressure on early cardiovascular changes in essential hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Impact of nocturnal fall in blood pressure on early cardiovascular changes in essential hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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