January 1, 1989Japanese Journal of MedicineOpen Access

Intrapericardial instillation of OK-432 for the management of malignant pericardial effusion. Report of three cases.

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Why the study?

Does intrapericardial instillation of OK-432 prevent reaccumulation of malignant pericardial effusion in patients with cardiac tamponade?

Population

3 patients with cardiac tamponade caused by malignant pericardial effusion.

Design

Case_series

Follow-up

Up to 14 months

Authors

TITakuroh ImamuraKoga Hospital KTKazuo TamuraFukuoka University TTToshifumi TaguchiYazaki (United States)

Discussion

Member takes

Implication

May control malignant pericardial effusion after pericardiocentesis in select cases; hypothesis-generating and requires prospective trials.

Structured PICO

Does intrapericardial instillation of OK-432 prevent reaccumulation of malignant pericardial effusion in patients with cardiac tamponade?

Population

3 patients (ages 50, 52, 42; 2 men, 1 woman) with cardiac tamponade caused by malignant pericardial effusion (underlying diseases: adenocarcinoma of unknown origin, breast cancer, and multiple myeloma).

Intervention

Pericardiocentesis followed by intrapericardial instillation of OK-432 (5 to 10 KE diluted in 20 ml of saline).

Outcome

Complete control of pericardial effusion for more than 30 days (no requirement for repeated pericardiocentesis).

Intrapericardial instillation of OK-432 following pericardiocentesis may effectively prevent the reaccumulation of malignant pericardial effusion and recurrent cardiac tamponade.

Limitations

Small sample size (3 cases)
Lack of autopsy to confirm the histological mechanism (e.g., pericardial adhesion)
Lack of serial cytological examination
Not a randomized controlled trial to assess survival benefit

Cite This Study

Imamura et al. (1989) studied this question.

synapsesocial.com/papers/6a708d1f87f921057127bf87 https://doi.org/10.2169/internalmedicine1962.28.62

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Implication

May control malignant pericardial effusion after pericardiocentesis in select cases; hypothesis-generating and requires prospective trials.

Intrapericardial instillation of OK-432 for the management of malignant pericardial effusion. Report of three cases.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Intrapericardial instillation of OK-432 for the management of malignant pericardial effusion. Report of three cases.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider