December 1, 1985Journal of Clinical Oncology
Tetracycline sclerosis in the management of malignant pericardial effusion.
Why the study?
Does intrapericardial tetracycline instillation safely and effectively control malignant pericardial effusion?
Population
22 patients with malignant pericardial effusion. Primary malignancies included lung, breast, stomach, ovary…
Design
Case_series
Follow-up
median survival 160 days (range 38 to 275 days)
Authors
Discussion
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Member takes
Implication
May warrant consideration in select malignant effusions; leaves open efficacy and safety without prospective trials.
Structured PICO
Does intrapericardial tetracycline instillation safely and effectively control malignant pericardial effusion?
P
Population
22 patients with malignant pericardial effusion (9 men, 13 women, median age 55 years). Primary malignancies included lung (15), breast (2), stomach (1), ovary (1), pleural mesothelioma (1), chronic granulocytic leukemia (1), and adenocarcinoma of unknown primary (1).
I
Intervention
Intrapericardial instillation of xylocaine hydrochloride 100 mg followed by tetracycline hydrochloride 500 to 1,000 mg dissolved in 20 mL normal saline, repeated every 24 to 48 hours until net drainage was less than 25 mL/24 hours.
O
Outcome
Control of malignant pericardial effusion for more than 30 dayshard clinical
Intrapericardial tetracycline instillation is a safe and efficacious treatment for controlling malignant pericardial effusion and preventing recurrence.
Cite This Study
Shepherd et al. (1985) studied this question.