Independent prognostic value of intravenous dipyridamole with technetium-99m sestamibi tomographic imaging in predicting cardiac events and cardiac-related hospital admissions
Why the study?
Does abnormal myocardial perfusion on intravenous dipyridamole Tc-99m sestamibi SPECT imaging predict cardiac events and hospital admissions?
Population
512 patients undergoing intravenous dipyridamole technetium-99m sestamibi single-photon emission computed…
Comparison
Abnormal myocardial perfusion on intravenous… vs Normal myocardial perfusion on intravenous…
Design
Cohort
Follow-up
mean 12.8 +/- 6.8 months
Authors
Discussion
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Member takes
Overview
Abnormal dipyridamole SPECT perfusion was associated with higher events; hypothesis-generating for risk stratification and requires prospective validation.
Structured PICO
Does abnormal myocardial perfusion on intravenous dipyridamole Tc-99m sestamibi SPECT imaging predict cardiac events and hospital admissions?
P
Population
512 patients undergoing intravenous dipyridamole technetium-99m (Tc-99m) sestamibi single-photon emission computed tomographic (SPECT) myocardial perfusion imaging
I
Intervention
Abnormal myocardial perfusion (fixed or reversible defects; small, moderate or large) on intravenous dipyridamole Tc-99m sestamibi SPECT imaging
C
Comparator
Normal myocardial perfusion on intravenous dipyridamole Tc-99m sestamibi SPECT imaging
O
Outcome
Occurrence of cardiac death or nonfatal myocardial infarction and other cardiac-related hospital admissionscomposite
Intravenous dipyridamole Tc-99m sestamibi SPECT imaging effectively stratifies short-term cardiac risk, with normal scans indicating an excellent prognosis and abnormal scans predicting higher rates of cardiac events.
Cite This Study
Heller et al. (1995) studied this question.