Population
Cells (in vitro model)
Comparison
Mechanical stress, expression of V12Rac, or… vs Unstretched cells or control conditions
Design
Preclinical
Authors
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Preclinical findings preclude clinical use; leaves open Rac as a mechanosensor in cardiovascular cell motility studies.
Mechanical tension regulates cell motility and polarization by modulating Rac activity, providing insight into how mechanical stress is transduced into biochemical signals.
Katsumi et al. (2002) studied this question.
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