Population
growing HeLa cells
Design
Preclinical
Authors
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Partial blockade in cell models is hypothesis-generating for Rac-MLC signaling; leaves open in vivo cytoskeletal relevance.
Active Rac causes phosphorylation of MLC in HeLa cells, implicating activation of actomyosin II ATPase activity as a mechanism for Rac-induced cytoskeletal changes.
Brzeska et al. (2004) studied this question.
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