Population
Primary avian myoblasts (unestablished avian myoblasts, quail myoblasts)
Design
Preclinical
Authors
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Stage-specific Rac1/Cdc42 activation impairs myogenic progression and sarcomere assembly; leaves open in vivo roles in muscle regeneration or disease.
Rac1 plays a critical role in skeletal muscle differentiation and is required downstream of v-Src in signaling pathways responsible for dismantling tissue-specific supramolecular structures.
Gallo et al. (1999) studied this question.
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