August 1, 2000Molecular Biology of the CellOpen Access

Critical Activities of Rac1 and Cdc42Hs in Skeletal Myogenesis: Antagonistic Effects of JNK and p38 Pathways

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Population

L6 and C2 myoblasts

Design

Preclinical

Authors

MMMayya MérianeUniversité du Québec à Montréal PRPierre RouxCentre National de la Recherche Scientifique MPMichael PrimigInserm

Discussion

Member takes

Implication

Delineates Rho GTPase control of myogenesis via MAPK antagonism; hypothesis-generating for muscle repair strategies pending mammalian validation.

Structured PICO

Population

L6 and C2 myoblasts

Intervention

Dominant negative and active forms of Rho family GTP-binding proteins (RhoA, RhoG, Rac1, Cdc42Hs)

Outcome

Expression of muscle-specific genes (myogenin, troponin T, and myosin heavy chain) and myoblast-to-myotube transitionsurrogate

This study demonstrates that Rho family proteins differentially regulate skeletal myogenesis through the antagonistic effects of the p38 and JNK MAPK pathways.

Cite This Study

Mériane et al. (2000) studied this question.

synapsesocial.com/papers/6a71addc660549caf2c6372f https://doi.org/10.1091/mbc.11.8.2513

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Implication

Delineates Rho GTPase control of myogenesis via MAPK antagonism; hypothesis-generating for muscle repair strategies pending mammalian validation.

Critical Activities of Rac1 and Cdc42Hs in Skeletal Myogenesis: Antagonistic Effects of JNK and p38 Pathways

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Critical Activities of Rac1 and Cdc42Hs in Skeletal Myogenesis: Antagonistic Effects of JNK and p38 Pathways

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider