April 10, 2006Cell Motility and the Cytoskeleton

Activation of myosin in HeLa cells causes redistribution of focal adhesions and F-actin from cell center to cell periphery

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Population

HeLa cells

Design

Preclinical

Authors

JSJoanna SzczepanowskaInstytut Biologii Doświadczalnej im. Marcelego Nenckiego EKEdward D. KornNational Institutes of Health HBHanna BrzeskaNational Institutes of Health

Discussion

Member takes

Implication

Cell study links myosin phosphorylation to cytoskeletal remodeling; leaves open relevance to cardiovascular cell function in vivo.

Structured PICO

Population

HeLa cells

Intervention

Expression of the constitutively active catalytic domain of ameba PAK

Outcome

Changes in focal adhesions, F-actin distribution, and myosin light chain phosphorylationsurrogate

Expression of the ameba PAK catalytic domain in HeLa cells demonstrates that direct myosin phosphorylation drives cytoskeletal changes and cell retraction.

Cite This Study

Szczepanowska et al. (2006) studied this question.

synapsesocial.com/papers/6a981bae923bb7518ba69cb2 https://doi.org/10.1002/cm.20125

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Activation of myosin in HeLa cells causes redistribution of focal adhesions and F-actin from cell center to cell periphery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Activation of myosin in HeLa cells causes redistribution of focal adhesions and F-actin from cell center to cell periphery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider