Population
Saponin permeabilized endothelial monolayers and in vitro models (placenta and recombinant proteins)
Design
Preclinical
Authors
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May blunt tension via MLCK inhibition in vivo; leaves open relevance to cardiovascular disease models.
PAK2 directly phosphorylates MLCK on serine residues 439 and 991, inhibiting its activity and limiting isometric tension development.
Goeckeler et al. (2000) studied this question.
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