Why the study?
Identifying mechanisms and therapeutic targets for cardiac atrophy resulting from mechanical or metabolic unloading may facilitate the development of effective treatments to prevent, attenuate, or reverse myocardial atrophy.
This review highlights the dual nature of myocardial atrophy, suggesting it may initially offer an anti-arrhythmic phenotype before progressing to heart failure.
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May heighten clinician awareness of unloading-related cardiac atrophy; leaves open effective therapeutic targets for prevention or reversal.
Bačová et al. (2022) studied this question.
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