Why the study?
Does advanced age attenuate glucose recovery from hypoglycemia in nondiabetic subjects?
Population
41 nondiabetic subjects, including 23 elderly subjects and 18 young subjects. A subset of 11 elderly…
Comparison
Hypoglycemia induced by 0.05 U/kg body wt… vs Young nondiabetic subjects and baseline
Design
Cohort
Follow-up
1 year (for physical training subset)
Authors
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May heighten hypoglycemia risk in elderly nondiabetics; leaves open extension to diabetes and therapeutic implications.
Does advanced age attenuate glucose recovery from hypoglycemia in nondiabetic subjects?
Advanced age is associated with impaired glucose counterregulation and attenuated recovery from hypoglycemia, driven by reduced glucagon responses and higher insulin concentrations.
Marker et al. (1992) studied this question.
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