Why the study?
Does induced hypoglycaemia produce different symptom awareness and counter-regulatory responses in elderly versus young healthy subjects?
Population
13 healthy non-diabetic subjects, comprising 6 young and 7 elderly.
Comparison
Hyperinsulinaemic glucose clamp lowering blood… vs Euglycaemic study where blood glucose remained…
Design
Other
Authors
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Elderly may have impaired hypoglycaemia awareness despite intact hormones; hypothesis-generating and requires prospective validation in diabetes.
Does induced hypoglycaemia produce different symptom awareness and counter-regulatory responses in elderly versus young healthy subjects?
Elderly individuals have reduced awareness of hypoglycaemia compared to younger individuals, likely due to an impaired end-organ response to counter-regulatory hormones rather than a blunted hormone response itself.
Brierley et al. (1995) studied this question.
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