Why the study?
Stroke is a leading cause of disability and death globally, and this meta-analysis aimed to evaluate the efficacy and safety of clopidogrel plus aspirin versus aspirin monotherapy in preventing recurrent stroke.
Does dual antiplatelet therapy with clopidogrel and aspirin reduce recurrent stroke compared to aspirin monotherapy in adult patients with acute stroke or TIA?
Population
15,376 adult patients with acute stroke or TIA across 33 studies
Comparison
DAPT with clopidogrel and aspirin vs aspirin monotherapy
Design
Systematic review and meta-analysis
Follow-up
Between 30 and 90 days
Authors
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Supports short-term DAPT over aspirin for lowering recurrent stroke in minor AIS/TIA; confirms efficacy from prior RCTs.
Does dual antiplatelet therapy with clopidogrel and aspirin reduce recurrent stroke compared to aspirin monotherapy in adult patients with acute stroke or TIA?
Dual antiplatelet therapy with clopidogrel and aspirin is more effective than aspirin monotherapy in reducing recurrent strokes in patients with acute stroke or TIA, though it may increase the risk of bleeding.
Bhutto et al. (2025) studied this question.
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