Why the study?
Do different AT1-receptor blockers (losartan, valsartan, irbesartan, candesartan) have different maximal efficacies in reducing diastolic blood pressure in adults with mild to moderate primary diastolic hypertension?
Population
Adult men and women with mild to moderate primary diastolic hypertension from randomized, double-blind…
Comparison
AT1-receptor blockers for at least 4 weeks vs Placebo
Design
Meta-analysis, randomized, double-blind, placebo-controlled
Follow-up
at least 4 weeks
Authors
Loading...
Favors candesartan over valsartan for maximal DBP reduction; confirms differential ARB efficacy in hypertension.
Do different AT1-receptor blockers (losartan, valsartan, irbesartan, candesartan) have different maximal efficacies in reducing diastolic blood pressure in adults with mild to moderate primary diastolic hypertension?
Candesartan demonstrates a significantly greater maximal antihypertensive effect on diastolic blood pressure compared to valsartan and losartan, indicating clinically relevant efficacy differences among AT1-receptor blockers.
Elmfeldt et al. (2002) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: