Myosin-linked calcium regulation in molluscan muscle contrasts with vertebrate thin-filament control; leaves open relevance to human cardiac muscle.
The mechanism of regulation in molluscan muscles differs from that in vertebrate muscle. In molluscan muscles calcium triggers contraction by interacting with myosin (Kendrick-Jones et al., 1970), whereas in vertebrate and arthropod muscles, calcium reacts with the components of the thin filaments (Ebashi and Kodama, 1965, 1966). In this paper we will compare these two control systems, pointing out similarities as well as some of the fundamental differences. We will show that the myosin-linked regulation is not restricted to molluscan muscles and will report on our other preliminary comparative studies. Finally we will discuss the possible changing role of the components involved in regulation during evolution.
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Lehman et al. (1973) studied this question.
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