A Catalyst Free Surfactant Mediated Multicomponent Synthesis of Quinazolinone Derivatives in Aqueous Media

A versatile and green synthetic protocol has been developed for synthesis of substituted quinazolinone and spiroquinazolinone heterocycles effectively via a combined surfactant mediated system. The use of Surfactant, water as reaction medium, room temperature, high yield and ease of purification made the process very effective and ecofriendly in nature. To demonstrate the wide scope of reaction Isatoic anhydride and Isatin used as reactants in different sets of reactions that leads to formation of Quinazolinones and spiroquinazolinones. A total of 12 derivatives has been prepared and characterized by all the spectroscopic data. The developed protocol presents a better and environmentally efficient methodology to get these heterocycles.