Population
Cell-free extracts of rabbit reticulocytes translating encephalomyocarditis viral RNA
Comparison
Dilution of incubation mixtures vs Dilution with untranslated reticulocyte extract…
Design
Preclinical
Authors
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No immediate clinical implications from this animal study; leaves open whether dual cleavage mechanisms can be exploited therapeutically.
Demonstrates that picornaviral replicase precursor protein C undergoes both intermolecular cleavage by a viral protease and intramolecular self-cleavage.
Palmenberg et al. (1982) studied this question.
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