Key result
The encephalomyocarditis protease responsible for cleaving coat precursor protein is a 20,000 molecular weight protein derived from protein D, a component of the viral RNA polymerase.
Population
Extracts from rabbit reticulocytes synthesizing encephalomyocarditis protease
Design
Preclinical
Authors
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May inform EMCV protease inhibitor design; leaves open clinical translation for viral myocarditis.
The protease required for processing picornaviral coat protein is derived from a component of the viral RNA polymerase.
Palmenberg et al. (1979) studied Encephalomyocarditis virus. The encephalomyocarditis protease responsible for cleaving coat precursor protein is a 20,000 molecular weight protein derived from protein D, a component of the viral RNA polymerase.
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