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February 17, 2014British Journal of PharmacologyOpen Access

BTB inhibited F1Fo-ATPase activity, decreased ATP consumption following inhibition of respiration, reduced ischaemic cell death, and rescued defective haemoglobin synthesis in zebrafish pnt mutants.

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Population

Several cell types and zebrafish pinotage (pnt) mutants

Design

Preclinical

Authors

FIFabrice IvanésDFDanilo FaccendaJGJemma Gatliff

Discussion

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Overview

May guide ischaemia-limiting therapies; leaves open clinical translation from animal data alone.

Structured PICO

P
Population
Several cell types and zebrafish pinotage (pnt) mutants
I
Intervention
BTB06584 (BTB)
O
Outcome
F1Fo-ATPase activity, ATP consumption, and ischaemic cell deathsurrogate

BTB06584 acts as an IF1-dependent selective inhibitor of mitochondrial F1Fo-ATPase, offering a potential mechanism to limit ischaemia-induced cellular injury.

Cite This Study

Ivanés et al. (2014) studied this question.

synapsesocial.com/papers/6a708f6eb27f1581782769dahttps://doi.org/10.1111/bph.12638
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