April 1, 2009American Journal of Psychiatry
Long-Term Use of Antidepressants for Depressive Disorders and the Risk of Diabetes Mellitus
Why the study?
Does long-term use of antidepressants increase the risk of incident diabetes mellitus in patients with depression?
Population
11,206 patients drawn from a cohort of 165,958 patients with depression, at least 30 years of age and…
Comparison
Recent long-term use of antidepressants in… vs No use of antidepressants during the past 2 years.
Design
Case-control
Authors
Discussion
Loading...
Member takes
Implication
May warrant glycemic monitoring in long-term moderate-to-high dose antidepressant users; leaves open causality and requires prospective confirmation.
Structured PICO
Does long-term use of antidepressants increase the risk of incident diabetes mellitus in patients with depression?
P
Population
11,206 patients (2,243 cases of incident diabetes mellitus and 8,963 matched comparison subjects) drawn from a cohort of 165,958 patients with depression, at least 30 years of age and without diabetes at cohort entry.
I
Intervention
Recent long-term use (>24 months) of antidepressants (including tricyclic antidepressants and selective serotonin reuptake inhibitors) in moderate to high daily doses.
C
Comparator
No use of antidepressants during the past 2 years.
O
Outcome
Incident diabetes mellitus.hard clinical
Long-term use of antidepressants in moderate to high daily doses is associated with a significantly increased risk of incident diabetes mellitus.
Cite This Study
Andersohn et al. (2009) studied this question.