Antidepressant Medication Use, Weight Gain, and Risk of Type 2 Diabetes
Why the study?
Does continuing antidepressant medication use increase the risk of incident type 2 diabetes and weight gain in working-aged adults?
Population
151,347 working-aged men and women from a prospective cohort, including 9,197 participants with continuing…
Comparison
Continuing antidepressant medication use vs Nonusers matched for depression-related…
Design
Cohort
Follow-up
mean 4.8 years
Authors
Discussion
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Member takes
Implication
May warrant diabetes surveillance in long-term users; leaves open causality and needs prospective confirmation.
Structured PICO
Does continuing antidepressant medication use increase the risk of incident type 2 diabetes and weight gain in working-aged adults?
P
Population
151,347 working-aged men and women from a prospective cohort (the Public Sector study, Finland 1995-2005), including 9,197 participants with continuing antidepressant medication, 224 with severe depression, and 851 with incident type 2 diabetes.
I
Intervention
Continuing antidepressant medication use (≥ 200 defined daily doses, including tricyclic antidepressants and selective serotonin reuptake inhibitors)
C
Comparator
Nonusers matched for depression-related characteristics, and diabetes-free control subjects
O
Outcome
Incident type 2 diabetes and self-reported weight gainhard clinical
Continuing use of antidepressant medication is associated with a modest absolute increase in the risk of developing type 2 diabetes and weight gain.
Cite This Study
Kivimäki et al. (2010) studied this question.