Population
Human arterial segments containing normal intima and adjacent fatty streak lesions
Comparison
Incubation with [2-(14)C]acetate vs Normal intima
Design
Preclinical
Authors
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May support local lipid synthesis in early lesions; hypothesis-generating and should not yet change practice.
Lipid synthesis is increased in human fatty streak lesions, suggesting local metabolism contributes to lipid accumulation in early atherosclerosis.
Chobanian et al. (1972) studied this question.
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