Population
Recombinant extracellular superoxide dismutase (rEC-SOD) variants and Chinese hamster ovary cells
Comparison
Amino acid exchanges, truncations, and… vs Parental A and C class EC-SOD forms
Design
Preclinical
Authors
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Identifies key EC-SOD residues for heparin affinity; leaves open effects on vascular distribution or therapeutic potential in cardiovascular models.
The cluster of six basic amino acids in the carboxyl-terminal end of EC-SOD forms the essential part of its heparin-binding domain, which is determined by the composition of its four subunits.
Sandström et al. (1992) studied this question.
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