Electrotonic metabolism of pacemaker activity. Further biological and mathematical observations on the behavior of modulated parasystole.
Population
In vitro biologic model using dog Purkinje fibers and a mathematical model of parasystole
Design
Preclinical
Authors
Discussion
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Implication
Rate-dependent shifts may alter ECG interpretation of ectopy; leaves open human translation of parasystole models.
Structured PICO
P
Population
In vitro biologic model using dog Purkinje fibers and a mathematical model of parasystole
I
Intervention
Superfusion of the central segment of a dog Purkinje fiber with an ion-free isotonic sucrose solution to provide a narrow region of block
O
Outcome
Modulation of pacemaker activity by electrotonic potentials transmitted across the area of block
Slight changes in heart rate, pacemaker rate, and block characteristics can significantly alter the patterns of ectopic activity in parasystole, as demonstrated in biologic and mathematical models.
Cite This Study
Antzelevitch et al. (1982) studied this question.