November 1, 2004Expert Review of Cardiovascular Therapy

Nesiritide for the treatment of decompensated heart failure

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Why the study?

Does nesiritide improve hemodynamics and clinical status in patients with acute decompensated heart failure?

Population

Patients with acute decompensated heart failure

Comparison

Nesiritide vs Other available intravenous agents for heart…

Design

Review

Authors

JWJohn V. WylieBoston Medical Center LTLana TsaoMassachusetts General Hospital

Discussion

Member takes

Implication

May support noninvasive use in acute decompensated heart failure; leaves open randomized confirmation of outcome benefits.

Structured PICO

Does nesiritide improve hemodynamics and clinical status in patients with acute decompensated heart failure?

Population

Patients with acute decompensated heart failure

Intervention

Nesiritide (synthetic analog of human B-type natriuretic peptide)

Comparator

Other available intravenous agents for heart failure

Outcome

Clinical status and hemodynamic parameters (cardiac filling pressures, cardiac index)surrogate

Nesiritide is an effective and well-tolerated intravenous treatment for acute decompensated heart failure that improves hemodynamics and clinical status without requiring invasive monitoring.

Cite This Study

Wylie et al. (2004) studied this question.

synapsesocial.com/papers/6a70962cfebe604dd7095b51 https://doi.org/10.1586/14779072.2.6.803

Topics

Heart failure HFrEF treatment

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Nesiritide for the treatment of decompensated heart failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Nesiritide for the treatment of decompensated heart failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider