November 16, 2016Frontiers in PharmacologyOpen Access

Cardiac STAT3 Deficiency Impairs Contractility and Metabolic Homeostasis in Hypertension

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Why the study?

Does STAT3 deficiency impair cardiac contractility and metabolic homeostasis in mice with Angiotensin II-induced hypertension?

Population

Male cardiomyocyte-targeted STAT3 knockout mice and wild type/Cre-expressing control mice

Comparison

Angiotensin II infusion via subcutaneous osmotic… vs Saline infusion via subcutaneous osmotic…

Design

Preclinical

Follow-up

28 days

Authors

RARaffaele AltaraHeart Failure / Cardiomyopathy RHRomain HarmanceyHeart Failure / Cardiomyopathy SDSean P. DidionUniversity of Mississippi Medical Center

Discussion

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Implication

Cardiac STAT3 role in hypertensive remodeling remains unclear in this model; leaves open its relevance to chronic stress.

Structured PICO

Does STAT3 deficiency impair cardiac contractility and metabolic homeostasis in mice with Angiotensin II-induced hypertension?

Population

Male cardiomyocyte-targeted STAT3 knockout (KO) mice and wild type (WT)/Cre-expressing control mice (2-4 months old, C57BL/6 background)

Intervention

Angiotensin II (1000 ng/kg/min) infusion via subcutaneous osmotic minipumps for 28 days

Comparator

Saline (0.9%) infusion via subcutaneous osmotic minipumps for 28 days

Outcome

Cardiac contractile function (ejection fraction and fractional shortening) and metabolic homeostasis (rates of glucose and oleate oxidation)surrogate

Cardiac STAT3 is essential for maintaining contractile function and metabolic homeostasis, but not for hypertrophic growth, during chronic hypertension-induced stress.

Limitations

Only male mice were used
Cannot preclude subtle subcellular differences between WT and Cre+ mice
Loss of STAT3 may have removed an ANG II-activated cardioprotective mechanism rather than a broad endogenous one
ANG II has both blood pressure-dependent and -independent effects

Cite This Study

Altara et al. (2016) studied this question.

synapsesocial.com/papers/6a70970aa7fbea1e44082071 https://doi.org/10.3389/fphar.2016.00436

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Cardiac STAT3 Deficiency Impairs Contractility and Metabolic Homeostasis in Hypertension

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Cardiac STAT3 Deficiency Impairs Contractility and Metabolic Homeostasis in Hypertension

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider