Why the study?
Does nitric oxide inhibit hepatocyte protein synthesis?
Population
Hepatocyte cultures
Comparison
Authentic nitric oxide and the NO.-generating… vs Unstimulated hepatocyte cultures or addition of…
Design
Preclinical
Authors
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NO may suppress hepatocyte protein synthesis independently of cGMP; leaves open relevance to human liver disease.
Does nitric oxide inhibit hepatocyte protein synthesis?
Nitric oxide inhibits hepatocyte protein synthesis through a translational or posttranslational mechanism independent of cGMP.
Curran et al. (1991) studied this question.
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