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October 22, 2008Radiology

Aortic Elasticity and Left Ventricular Function after Arterial Switch Operation: MR Imaging—Initial Experience

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Why the study?

Does the arterial switch operation affect aortic elasticity and LV function in adolescent patients compared to healthy controls?

Population

30 participants: 15 patients evaluated 16.1 +/- 3.7 years after the arterial switch operation, and 15 age…

Comparison

Arterial switch operation evaluated by magnetic… vs Age- and sex-matched healthy control subjects

Design

Cross-sectional

Follow-up

16.1 years +/- 3.7 after surgery

Authors

HGHeynric B. GrotenhuisPrincess Máxima CenterJOJaap OttenkampAmsterdam UMC Location University of AmsterdamDFD.B.Y. FonteinUniversity Hospital of Zurich

Discussion

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Implication

May warrant closer monitoring for aortic and LV dysfunction post-ASO in adolescents; hypothesis-generating without longitudinal data.

Structured PICO

Does the arterial switch operation affect aortic elasticity and LV function in adolescent patients compared to healthy controls?

P
Population
30 participants: 15 patients (11 male, 4 female; mean age 16 +/- 4 years) evaluated 16.1 +/- 3.7 years after the arterial switch operation (ASO), and 15 age- and sex-matched control subjects.
I
Intervention
Arterial switch operation (ASO) evaluated by magnetic resonance (MR) imaging
C
Comparator
Age- and sex-matched healthy control subjects
O
Outcome
Aortic dimensions, aortic elasticity (pulse wave velocity and aortic root distensibility), aortic valve competence (AR fraction), and left ventricular (LV) systolic function (LVEF, EDV, ESV)surrogate

Patients who have undergone the arterial switch operation frequently exhibit aortic root dilatation, reduced aortic elasticity, minor aortic regurgitation, and impaired LV systolic function on MR imaging.

Cite This Study

Grotenhuis et al. (2008) studied this question.

synapsesocial.com/papers/6a709b973ce530166bc2df69https://doi.org/10.1148/radiol.2492072013
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Also Consider

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  4. 4Arterial Stiffness: A New Cardiovascular Risk Factor?1994 · 485 citations
  5. 5Regional aortic compliance studied by magnetic resonance imaging: the effects of age, training, and coronary artery disease.1989 · 278 citations