Key result
Asymptomatic patients who underwent arterial switch operation for d-TGA had significantly impaired global LV longitudinal strain compared to controls (-19.2% vs. -22.7%, P < 0.0001).
Why the study?
Does single-stage arterial switch operation for d-TGA affect left ventricular mechanics in asymptomatic patients with normal ejection fraction compared to controls?
Observational (n=93)
Does single-stage arterial switch operation for d-TGA affect left ventricular mechanics in asymptomatic patients with normal ejection fraction compared to controls?
Absolute Event Rate: -19.2% vs -22.7%
p-value: p=< 0.0001
Asymptomatic patients who underwent arterial switch operation for d-TGA have impaired left ventricular longitudinal strain despite normal ejection fraction, which correlates with older age at surgery.
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Impaired LV strain post-ASO in asymptomatic d-TGA patients with normal EF may indicate subclinical dysfunction; leaves open prognostic value and follow-up implications.
Salvo et al. (2016) conducted an observational in dextro-transposition of the great arteries (d-TGA) (n=93). Arterial switch operation (ASO) vs. Age and sex comparable controls was evaluated on Global LV longitudinal strain (p=< 0.0001). Asymptomatic patients who underwent arterial switch operation for d-TGA had significantly impaired global LV longitudinal strain compared to controls (-19.2% vs. -22.7%, P < 0.0001).
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