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December 16, 2004HeartOpen Access

Fractional shortening, ejection fraction, and VCFc were significantly lower in patients than in controls at rest (all p < 0.001), and dobutamine stress echocardiography unmasked wall motion abnormalities in 23 (74%) patients.

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Why the study?

Does dobutamine stress echocardiography detect impaired left ventricular function in children long term after arterial switch operation for transposition of the great arteries?

Population

31 children with prior arterial switch operation for transposition of the great arteries performed at mean…

Comparison

Dobutamine stress echocardiography vs 20 healthy age-matched control participants

Design

Cross-sectional

Follow-up

mean 9.4 years after operation

Authors

LHLai Ling Hui

Discussion

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Overview

May identify subclinical LV dysfunction in asymptomatic post-ASO children; leaves open whether stress echocardiography should guide management.

Structured PICO

Does dobutamine stress echocardiography detect impaired left ventricular function in children long term after arterial switch operation for transposition of the great arteries?

P
Population
31 children (24 boys) with prior arterial switch operation (ASO) for transposition of the great arteries performed at mean 15.5 days of life, studied at mean age 9.4 years, all with normal coronary angiographic findings.
I
Intervention
Dobutamine stress echocardiography
C
Comparator
20 healthy age-matched control participants
O
Outcome
Left ventricular echocardiographic indexes (fractional shortening, ejection fraction, rate corrected velocity of circumferential fibre shortening [VCFc], and wall stress) and wall motion abnormalities at rest and under dobutamine stresssurrogate

A significant proportion of asymptomatic children have impaired baseline LV contractility and reversible myocardial perfusion defects long term after arterial switch operation.

Cite This Study

Lai Ling Hui (2004) studied this question.

synapsesocial.com/papers/6a86ad36a810ea404bcf7b2fhttps://doi.org/10.1136/hrt.2003.027524
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Left ventricular remodelling in long-term survivors after the arterial switch operation for transposition of the great arteries2018 · 32 citations
  2. 2Left ventricular mechanics after arterial switch operation2016 · 29 citations
  3. 3Left ventricular performance following the arterial switch operation1998 · 23 citations
  4. 4D-Transposition of the Great Arteries after Arterial Switch Operation: Usefulness of 3D-Echocardiography for Left Ventricle Function Evaluation2020
  5. 5Left ventricular contractile reserve after arterial switch operation for complete transposition of the great arteries: an exercise echocardiographic study2012 · 24 citations