Why the study?
Do calcium antagonists provide benefit in patients with chronic heart failure?
Do calcium antagonists provide benefit in patients with chronic heart failure?
Current evidence does not support the routine use of calcium antagonists for established chronic heart failure.
Does not support calcium antagonists in established heart failure; leaves open possible diastolic benefits in coronary disease with reduced ejection fraction but no overt failure.
Calcium antagonists have been widely used for the treatment of angina and hypertension. Because of vasodilator and anti-ischaemic properties, calcium antagonists might be expected to bring benefit to patients with heart failure, particularly when the heart failure is due to coronary heart disease. Eight trials of calcium antagonists, fulfilling specific criteria, have been reviewed. The evidence at present does not support the use of calcium antagonists in established heart failure. Some benefit may accure from the use of the newer calcium antagonists but further trials are awaited. Calcium antagonists appear to improve diastolic fraction in patients with coronary heart disease, no overt heart failure but a reduced ejection fraction.
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Parameshwar et al. (1993) studied this question.
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