Why the study?
Does specific antihypertensive therapy reduce left ventricular hypertrophy and ventricular arrhythmias in patients with arterial hypertension?
Does specific antihypertensive therapy reduce left ventricular hypertrophy and ventricular arrhythmias in patients with arterial hypertension?
Reducing left ventricular hypertrophy with antihypertensive therapy may decrease ventricular arrhythmias and the risk of sudden death.
LVH is a common sequela of arterial hypertension; it increases the risk of sudden death and other cardiovascular morbidity and mortality independent of arterial pressure and has been associated with ventricular arrhythmias. Electrophysiological studies suggest a connection between ventricular arrhythmias in patients with LVH and sudden death. LVH can be reduced by specific antihypertensive therapy, although not all drugs are equipotent in this regard. A reduction in LVH has been shown to diminish ventricular ectopy. Preliminary findings suggest that a reduction of LVH and associated arrhythmias may reduce its inherent cardiovascular risk.
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Messerli et al. (1992) studied this question.
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