Why the study?
Cardiovascular complications are the leading cause of morbidity and mortality in diabetes mellitus, but little is known about the mechanisms connecting diabetes mellitus to cardiovascular dysfunction.
Nuclear miR-320 acts as a small activating RNA to induce CD36 expression and lipotoxicity, presenting a novel mechanism and potential therapeutic target for diabetic cardiomyopathy.
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Preclinical db/db findings warrant no practice change; leaves open translational relevance to human diabetic cardiomyopathy.
Li et al. (2019) studied this question.
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