Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes

Mathis K. Stokke; Karina Hougen; Ivar Sjaastad; William E. Louch; Sarah J. Briston; Ulla Enger; Kristin B. Andersson; Geir Christensen; David Eisner; Ole M. Sejersted; Andrew W. Trafford

doi:10.1093/cvr/cvp401

December 17, 2009Cardiovascular ResearchOpen Access

Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes

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Structured PICO

P

Population

SERCA2 knockout [Serca2(flox/flox) Tg(alphaMHC-MerCreMer); KO] mice allowing inducible cardiomyocyte-specific disruption of the Serca2 gene in adult mice

I

Intervention

Cardiomyocyte-specific disruption of the Serca2 gene (SERCA2 knockout)

C

Comparator

Serca(flox/flox) (FF) control mice

O

Outcome

Propensity for Ca2+ wave developmentsurrogate

Reduced SERCA2 abundance in a mouse model decreases the propensity for arrhythmogenic Ca2+ wave development and ventricular extrasystoles.

Implication

Supports SERCA2 reduction suppressing Ca waves in mice; hypothesis-generating, no clinical implications yet.

Discussion

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Cite This Study

Stokke et al. (2009) studied this question.

synapsesocial.com/papers/6a709e42e36a167817e26f46 https://doi.org/10.1093/cvr/cvp401

View Full Paper

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Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes

Structured PICO

Implication

Discussion

Cite This Study

Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes

Structured PICO

Implication

Discussion

Cite This Study

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