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May 1, 2003Circulation Research

Ca 2+ Uptake by the Sarcoplasmic Reticulum in Ventricular Myocytes of the SERCA2 b/b Mouse Is Impaired at Higher Ca 2+ Loads Only

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Population

Isolated cardiac myocytes from SERCA2b/b mice

Comparison

SERCA2b/b mutation vs Wild-type (WT) mice

Design

Preclinical

Authors

GAGudrun AntoonsMHMark Ver HeyenLRLuc Raeymaekers

Discussion

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Overview

May alter Ca2+ handling selectively at high loads in SERCA2b mice; leaves open translation to human HF or isoform-targeted therapies.

Structured PICO

P
Population
Isolated cardiac myocytes from SERCA2b/b mice (mice with a mutation of Atp2a2 resulting in full suppression of the SERCA2a isoform and expression of the SERCA2b isoform only)
I
Intervention
SERCA2b/b mutation
C
Comparator
Wild-type (WT) mice
O
Outcome
Ca2+ handling parameters including amplitude of [Ca2+]i transients, SR Ca2+ content, diastolic [Ca2+]i, density of ICaL, and decline of [Ca2+]isurrogate

In SERCA2b/b mice, the higher Ca2+ affinity of the SERCA2b isoform partially compensates for reduced expression, impairing Ca2+ uptake only at higher Ca2+ loads.

Cite This Study

Antoons et al. (2003) studied this question.

synapsesocial.com/papers/6a73ff475e45dc7750a8ca55https://doi.org/10.1161/01.res.0000069032.81501.98
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Flux of Ca2+ across the sarcoplasmic reticulum of guinea‐pig cardiac cells during excitation‐contraction coupling.1991 · 209 citations
  2. 2A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes.1994 · 1,597 citations
  3. 3Replacement of the Muscle-Specific Sarcoplasmic Reticulum Ca 2+ -ATPase Isoform SERCA2a by the Nonmuscle SERCA2b Homologue Causes Mild Concentric Hypertrophy and Impairs Contraction-Relaxation of the Heart2001 · 105 citations
  4. 4Disruption of a Single Copy of the SERCA2 Gene Results in Altered Ca2+ Homeostasis and Cardiomyocyte Function2000 · 122 citations
  5. 5Impaired Cardiac Performance in Heterozygous Mice with a Null Mutation in the Sarco(endo)plasmic Reticulum Ca2+-ATPase Isoform 2 (SERCA2) Gene1999 · 265 citations