Why the study?
Does cyclosporin A impair acetylcholine-induced vasodilation in renal microvessels of rats?
Population
Rats with induced hydronephrosis
Comparison
Cyclosporin A (60 mg/kg/day s.c. for 5 days) vs Vehicle (olive oil)-treated control rats
Design
Preclinical
Follow-up
5 days
Authors
Loading...
May contribute to CsA nephrotoxicity via renal microvascular endothelial dysfunction in rats; hypothesis-generating and should not yet change practice.
Does cyclosporin A impair acetylcholine-induced vasodilation in renal microvessels of rats?
Cyclosporin A impairs endothelium-dependent, nitric oxide-mediated vasodilation in renal microvessels, which may contribute to its nephrotoxicity.
Takenaka et al. (1992) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: