May 1, 1996Transplantation

Clinically Relevant Doses and Blood Levels Produce Experimental Cyclosporine Nephrotoxicity When Combined With Nitric Oxide Inhibition1

View Full Paper

Ask AI

Bookmark

Why the study?

Does Cyclosporine combined with nitric oxide inhibition increase nephrotoxicity and blood pressure in Sprague-Dawley rats?

Population

Sprague-Dawley rats kept on a normal salt (+NaCl) or low-salt (-NaCl) diet

Comparison

Cyclosporine 7.5 mg/kg or 2.5 mg/kg for 21 days… vs Vehicle preceded by one week of L-NAME and…

Design

Preclinical

Follow-up

28 days

Authors

MGMichael P. GardnerUniversity of Birmingham DHDonald C. HoughtonOregon Health & Science University TATakeshi F. AndohOregon National Primate Research Center

Discussion

Member takes

Implication

CsA plus L-NAME markedly reduces GFR and elevates BP in rats; leaves open whether NO augmentation protects against cyclosporine nephrotoxicity in patients.

Structured PICO

Does Cyclosporine combined with nitric oxide inhibition increase nephrotoxicity and blood pressure in Sprague-Dawley rats?

Population

Sprague-Dawley rats kept on a normal salt (+NaCl) or low-salt (-NaCl) diet

Intervention

Cyclosporine (CsA) 7.5 mg/kg or 2.5 mg/kg for 21 days, preceded by one week of L-NAME (nitric oxide blockade) and continued for three weeks

Comparator

Vehicle (VH) preceded by one week of L-NAME and continued for three weeks, or CsA alone

Outcome

Inulin clearance (GFR), CsA blood level, weekly blood pressure change, and renal morphologic lesions at 28 dayssurrogate

Acute cyclosporine nephrotoxicity and blood pressure elevations are enhanced by simultaneous nitric oxide blockade in rats, suggesting NO has a protective effect in CsA-induced nephropathy.

Cite This Study

Gardner et al. (1996) studied this question.

synapsesocial.com/papers/6a8a882906e1858e55de93f4 https://doi.org/10.1097/00007890-199605270-00017

View Full Paper

Ask AI

Bookmark

Implication

CsA plus L-NAME markedly reduces GFR and elevates BP in rats; leaves open whether NO augmentation protects against cyclosporine nephrotoxicity in patients.

Clinically Relevant Doses and Blood Levels Produce Experimental Cyclosporine Nephrotoxicity When Combined With Nitric Oxide Inhibition1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Clinically Relevant Doses and Blood Levels Produce Experimental Cyclosporine Nephrotoxicity When Combined With Nitric Oxide Inhibition1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider