Why the study?
Does cyclosporine A induce hypertension through PKC activation and inhibition of endothelial NO formation in rats?
Population
Male Sprague-Dawley rats weighing 250 to 300 g and isolated rat aortic rings
Comparison
Cyclosporine A in olive oil by intraperitoneal… vs Vehicle by intraperitoneal injection
Design
Preclinical
Follow-up
7 days
Authors
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Hypothesis-generating for cyclosporine hypertension mechanisms in rats; leaves open translation to human therapy.
Does cyclosporine A induce hypertension through PKC activation and inhibition of endothelial NO formation in rats?
Cyclosporine A-induced hypertension is mediated in part by PKC activation, which inhibits endothelial nitric oxide formation, an effect reversible by L-arginine.
G.K. Oriji (1999) studied this question.
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